ABSTRACT
Propiciar aos residentes da área da Saúde, principalmente os trabalham nos Setores de Emergência Hospitalar, informações a respeito do fenômeno do suícidio tem crescido de maneirasignificativa e que o profissional da saúde poderá durante sua carreira se defrontar com um seu paciente que passe por essa tragédia, o conhecimento desse comportamento é de importância fundamental para que possa dar o tratamento ou o encaminhamento mais eficaz para aquela pessoa que se apresenta com esse problema
Subject(s)
Medical Staff, Hospital , Internship and Residency , Emergency Service, Hospital , Suicide/prevention & controlABSTRACT
Efforts to characterize HIV-1 polymorphism and anti-HIV immune response are being made in areas where anti-HIV/AIDS vaccines are to be employed. Anti-HIV-1 humoral immune response is being studied in infected individuals resident in Rio de Janeiro, in distinct cohorts involving recent seroconvertors, pregnant women or intravenous drug users (IDU). Comparative analysis of specificity of antibody response towards epitopes important for anti-HIV-1 immune response indicate quantitative differences between cohorts, with an exceptionally strong response in IDUs and weakest response in pregnant women. However, a comparative analysis between pregnant women cohorts from Rio de Janeiro and Rio Grande do Sul indicated an even lower response (with exception of the anti-V3-C clade peptide recognition) for the southern cohort. Studied analysing the immune function of the humoral response indicate a quite elevated occurrence of antibodies capable of neutralizing heterologous primary HIV-1 isolates from Rio de Janeiro. Attempts to correlate seroreactivity with HIV-1 neutralization with respect to HIV-1 polymorphism were not very successfull: while the Brazilian B clade B" variant could be recognized by binding assays, no significant distinction of HIV-1 clades/variants was observed in viral neutralization assays.